Stanford Case Study - 1832 Words

The Stanford group has performed a series of clinical trials using CD34+ purified cell transplants to induce tolerance to an HLA matched and mismatched living kidney donation. The first six patients were transplanted between 2000 and 2003 and had HLA-disparate donors104. Both related and unrelated patient/donor pairs ranged from a 3/6 to 0/6 HLA match. Six weeks before transplantation, the donors were treated with five doses of G-CSF for bone marrow mobilization. They then completed leukapheresis to harvest the peripheral blood mononuclear cells. The researchers selected the CD34+ mononuclear cells using a magnetic bead column resulting in 75% purity. Recipient conditioning included IV infusion of 1.5mg/kg rabbit ATG on days 1,†¦show more content†¦In addition, patients received a standard dose of MMF for 30 days after the infusion of donor cells. Between 6 months and 14 months post-transplant, 17 of 22 patients were successfully removed from IS. Of these, seven pat ients maintained stable chimerism for up to eight years (REF: Busque, Relationship Between Mixed Chimerism and Tolerance in HLA-Matched and -Mismatched Recipients of Kidney and Hematopoietic Cell Transplants. 2017, ATC). Nine experienced transient chimerism with donor cells lost at or around the time of IS taper. All but one have been able to maintain their IS-free status until their most recent follow-up (2 to 96 months off IS). All patients with stable, durable chimerism had a peak level of chimerism above 65% in their first two months after transplant. Of those that showed transient chimerism, six patients had a peak chimerism below 65%. This suggested a target for a chimerism peak for future studies 105,106. The final group of HLA haplotype mismatched patients was transplanted under a similar protocol as part of a dose escalation of the CD3+ cell addback to the donor infusion in order to promote durable mixed chimerism for at least six months while avoiding GVHD. Since 2013, ten patients have been treated under the protocol. The patients received between 8Ãâ€"106 and 22Ãâ€"106 CD34+ cells/kg. The first patient also received 3Ãâ€" 106 cells/kg of CD3+ T cells.Show MoreRelatedEssay on Case Study: R Allen Stanford928 Words   |  4 PagesKevin Han Case #1: Stanford Financial R. Allen Stanford is accused of pulling off a $7 billion Ponzi scheme that defrauded thousands of investors. Prosecutors allege that Stanford lured investors to purchase Certificate of Deposits with returns that were consistently higher than the market and used the proceeds to finance his lavish lifestyle. Stanford currently faces 14 criminal charges, including wire and mail fraud, in addition to civil suit from the SEC. 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